Sickle cell anemia : reexamining the first molecular disease / Simon D. Feldman and Alfred I. Tauber.
Abstract:
'... our account shows how definitions of the disorder developed around new and shifting scientific categories as laboratory-based evidence played an increasingly important role in the definition of the sickle cell disorder. Thus, the prevalence of clinical (patient-oriented) studies in the period between 1910 and the late 1920s is contrasted with the dominant laboratory-based strategies that followed. As research paradigms shifted and collided, so did the relative weight of clinical, cellular, hereditary, and chemical/molecular evidence as criteria in the assessment of the status of the disease.'
Bulletin of the history of medicine Vol. 71 (1997), p. 623-650